Analytical Toxicology and the Neurochemistry of Hallucinogens. Steven A. Barker, Ph.D., University of Alabama in Birmingham. Research into the adsorption, distribution, metabolism and clearance of hallucinogens, their mechanisms of action and their role as naturally occurring neurohormones. Studies are directed at characterization of neural pathways affected by hallucinogens and their related roles in the regulation of perception/cognition in health and disease. Research into the adsorption, distribution, metabolism and clearance of other drugs, particularly those that may affect the performance of racehorses, is also conducted.
McIlhenny, E.H., Riba, J., Barbanoj, M.J., Strassman, R, and Barker, S.A. 2012. Methodology for the determination of ayahuasca’s major constituents and their metabolites in blood. J. Biomed. Chromatogr. 26, 301-313.
Riba, J., McIlhenny, E.H., Valle, M., Bouso, J.C. and Barker, S.A. 2012. Metabolism and disposition of N,N-dimethyltryptamine and harmala alkaloids after oral administration of ayahuasca. Drug Test. Analys. 4, 610-616.
Barker, S.A., McIlhenny, E.H. and Strassman, R. 2012, A critical review of reports of endogenous psychedelic N,N-dimethyltryptamines in humans: 1955-2010. Drug Test. Analys. 4, 617-635.
Da Cuna, A.F., Messenger, K.M., Stout, R.W., Barker, S.A., Nevarez, J.G., Queiroz-Wlliams, P. and Tully, T.N. 2012. Pharmacokinetics of lidocaine and its active metabolite monoethylglycinexylidide (MEGX) after a single intravenous administration in chickens (Gallus domesticus) anesthetized with isoflurane. J. Vet. Pharmacol. Toxicol., 35, 604-607.
Linardi, R.L., Stokes, A.M., Keowen, M., Barker, S.A., Hosgood, G. and Short, C.R. 2012. Bioavailability and pharmacokinetics of oral and injectable formulations of methadone after intravenous, oral, and intragastric administration in horses. Amer. J. Vet. Res. 73, 290-295.
Thompson, J.A., Susan C. Eades, McConnico, R.S., D.B., Chapman, A.M. and Barker, S.A. 2012. Effects of clenbuterol administration on biochemical, histologic and echocardiographic measurements of muscle injury in exercising horses. Amer. J. Vet. Res. 73, 875-883.
McIlhenny, E.H., Riba, J., Barbanoj, M.J., Strassman, R. and Barker, S.A. 2011. Methodology for and the determination of the major constituents and metabolites of the Amazonian botanical medicine ayahuasca in human urine. J. Biomed. Chromatogr. 25, 970-984.
Thompson, J.A., Mizra, M.H., McConnico, R.S., Barker, S.A., Morgan, T.W. and Bauer, R.W. 2011. Clenbuterol toxicosis in three quarter horse racehorses after administration of a compounded product. J. Amer. Vet. Med. Assn. 239: 842-849.
dos Santos, R.G., Valle, M., Bouso, J.C., Nomdedeu, J.F., Rodriguez-Espinosa, J., McIlhenny, E.H., Barker, S.A., Barbanoj, M.J. and Riba, J. 2011. Autonomic, neuroendocrine and immunological effects of Ayahuasca. A comparative study with d-amphetamine. J. Clin. Psychopharmacol. 31, 1-10.